Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 4 (Feb. 15, 1987), pp. 950-954 (5 pages) We examined the roles of DNA topoisomerases in the replication of ...

Problems in DNA replication can induce chromosome rearrangements that are often associated with pathological disorders. Natural elements such as unusual DNA structures, fragile zones and DNA-binding ...

Vaccinia virus encodes a type I DNA topoisomerase that is highly conserved in all known poxviruses. Although the structure and catalytic activity of the enzyme were well studied, little was known ...

Transcription and replication occur at high frequency in cells. As they share the same DNA template, a high incidence of encounters is expected between the transcription and replication machineries, ...

Researchers have found the first evidence that cancer cells’ DNA replication machinery can react to drug treatment with a repair process called fork reversal. In research recently published in Nature ...

Cells have to carry around a massive amount of genetic material, and usually, that DNA is about 1,000 times longer than the cell where it lives. It can’t just be jammed in there though; it has to be ...

Chromosomal translocations leading to chimeric oncoproteins are important in leukemogenesis, but how they form is unclear. We studied acute promyelocytic leukemia (APL) with the t(15;17) translocation ...

(Philadelphia, PA) - Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA. The enzyme, called a ...

Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at the University of Seville in CABIMER) and with PharmaMAR, has identified ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published in ...

Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal ...

The annoying bulges of an over-wound telephone cord that shorten its reach and limit a caller's motion help to explain why drugs called camptothecins are so effective in killing cancer cells, ...