A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.

Germline pathogenic variants in BRCA1/BRCA2 are associated with ovarian cancer, fallopian tube cancer, primary peritoneal cancer, male breast cancer, prostate cancer, pancreatic …

A gene that makes a protein that repairs damaged DNA. Mutations (changes) in the BRCA2 gene significantly increase the risk of developing breast and ovarian cancer.

Hoja informativa sobre los genes BRCA1 y BRCA2, qué hacer si la prueba de una persona indica que tiene cambios en uno de estos genes y las consecuencias de las pruebas genéticas.

Feb 14, 2025 · BRCA2 is a protein that is involved in repairing DNA and maintaining the integrity of the genome in mammals, and variants in the gene that encodes BRCA2 are linked to …

Feb 14, 2025 · Rates of breast cancer in individuals with PALB2 pathogenic variants are similar to those associated with BRCA2. However, individuals with PALB2 and BRCA2 pathogenic …

NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer. From this research, a screening test was also …

Apr 15, 2024 · For women in whom gene testing finds “harmful changes” in the BRCA1 or BRCA2 genes, leading medical groups recommend that they take specific actions to lower their …

Dec 2, 2025 · Bilateral mastectomy has been shown to reduce the risk of breast cancer by at least 95% in women who have a harmful (disease-causing) variant in the BRCA1 gene or the …

A fact sheet about genetic testing for inherited cancer risk. Includes who should consider testing, and how to understand test results.